From the you’ve-probably-already-read-this file, Shack News conducted an interview with BethSoft PR Gorilla Pete Hines. The big take away from this interview seems to be the confirmation of minimal DRM for Fallout 3’s PC version:
Shack: Similar question in the sense that it’s an issue that can be overblown. What kind of copy protection will be included on the PC version of Fallout 3?
Pete Hines: Pretty similar to what we did for Oblivion, which was–we basically don’t do any–we do the mildest form possible. I actually don’t know if I even want to get into what it is that we exactly do, but we try to be really noninvasive when it comes to that stuff. [ed- Oblivion employed a simple DVD check.]
The rest of the interview is over yonder.