There’s a large and detailed Fallout 3 preview at Gameplayer, here is a small snip:
You can switch between first and third person at any time. The objects you can select in V.A.T.S differ per enemy. For example, when we were attacked by giant ants, we could aim to shoot for their Antenna. Without these the things lost perspective and went berko, often attacking other ants. Weapons will gradually degrade and when weakened will be more likely to jam. But you can pillage other versions of the same weapon for parts to ensure you always have one at full strength. You can kill someone with a teddy bear. You have to find the teddy bear, then use it as ammo, and then get real lucky. But still, we love the option… You can build your own weapons from scrap you find lying around: all you need is the components, the schematics and a workbench. We heard of one involving a leaf-blower and a vacuum. Weapon, or sex toy… time will tell. There are mini-games to enjoy, like lock-picking, and tuning in you Pip-boy to find radio signals which may give you directions to quests and survivors. The Bloody Mess perk is in the game, as are a host of others. Pete Hines claimed that you will receive a perk every time you level up. Then later said you level up 19 times to a maximum of 20. Which means around 19 perks by out maths.
There’s a lot more where this came from, and I really mean a lot! Spotted at NMA.